Some of my nearest and dearest in sl may have recently picked up on one of my new favorite things to do here. (No, not 7 seas fishing or even sailing!) What I mean is FEWD! Yes that's right… I am a kitchen MASTER! The particular kitchen I used in this post is from Dutchie and I've had it in my skybox for close to a month now. I decided to bake some cookies in it today since Le Bistro, one of my most favorite SL food places, was having a charity event to benefit the fight against kidney disease. The event is going to last through April 1st so you need to hurry up! you also get a 200L gift card with the purchase of these cookies. All the food at Le Bistro is "cook-able" and lets you actually prepare the meals and then sit down with your family and friends to enjoy what you made!

I'm wearing the new skin from Kento called Trent. Hair from Exile. New mesh sweats from KAPONE, tank top is from Zaara, tattoo is from Aitui and shoes from SOREAL.

Irritable Bowel Syndrome is something that I still have to deal with and is very much a challenge for me day by day.

It is possible over time and with experience to learn which foodstuffs trigger IBS and which are less problematic.  While everyone is of course unique there is a core of certain foods, which are likely to cause IBS symptoms.

Stress can be a cause of IBS, but so too is sugar and that is something I have touched on briefly but not in too much detail. Unfortunately it's not so obvious for most of us which foods contain sugar. The less obvious foods become obvious when we learn about those foods, particularly when we begin to eat them more frequently and don't realise that they can be a problem.

A study that has been carried out by researchers in Australia has suggested that a diet low in certain natural sugars may help people who struggle with IBS and inflammatory bowel disease.

Their theory is based on a low FODMAP diet, described as short-chain carbohydrates, found in many common foods. They began to look at the role of certain foods that are responsible for some of the symptoms we commonly have to deal with. Taking these foods out of our diet may help us reduce some of the IBS and inflammatory bowel disease symptoms.

These carbohydrates known as FODMAPs, represent the foods that are prone to fermentation brought about by gut bacteria. Some of the FODMAP foods include wheat, onion, garlic, artichokes, beans, lentils and peas, milk products, apples, pears, mangos, apples and cauliflower, most of which you wouldn't necessarily associate with IBS symptoms.

Taking some of these trigger foods out of our diet should significantly improve our symptoms. Because of the severity of the problem associated with IBS or inflammatory bowel disease, always consult and discuss your wishes you're your doctor first.

A new type of breast implant was recently created by Brown University researchers, which is reputed to repel cancerous cells. What makes this implant different is its ridged surface. The scientists created a surface for the breast implant that is made of a surgical grade polymer, which has microscopic raised lumps, similar to a bed of nails. This surface deters malignant breast cancer cells from attaching to the implant.

The scientists built the implant's polymer casing themselves, using polystyrene beads (23 nanometers in diameter) and attaching them to an FDA-approved biodegradable polymer often used for stitches and other clinical applications. They formed a cast on a sheet of class and began testing. They also created other versions with different sizes of the polystyrene beads. They tried 200- and 300-nanometer beads, but found that the 23 nanometer beads were the best for repelling the cancer's regrowth. To put size in perspective, one nanometer is equal to a millionth of a millimeter. There are 25.4 millimeters in an inch. The beads would be almost impossible to see without a microscope.

The researchers believe that polystyrene beads less than 23 nanometers may be even more effective than they currently are, however, beads that minuscule do not exist yet. The researchers will be conducting their experiment with different materials, trying to produce the similar result. They will also be experimenting to find out exactly why these nano-modified surfaces deter malignant cells.

Currently, roughly one in eight American women will be diagnosed with breast cancer in their lifetime. These women will have to undergo chemotherapy such as Arimidex or Femara, surgery such as a lumpectomy or mastectomy, and often choose to have reconstructive surgery. However, there is always the chance of a relapse, of the cancer growing back. That is where this deterrent implant would come in. Breast cancer cells would hopefully be unable to attach to the implant, and without an "anchor" it would be much more difficult for them to multiply. This is great news for women who have already undergone stressful hormone and chemotherapy, or painful surgery and rehabilitation. With these implants, they could have a beautiful reconstructed breast (or pair of breasts) without having to worry about their cancer returning.

If you are diagnosed with breast cancer, your doctor will often recommend hormone therapy drugs for you. Cancer medications are some of the most expensive on the market today, costing hundreds of dollars for only a week's supply. However, you can often save a significant amount by buying online from a Canadian pharmacy. You can buy Femara or generic Arimmidex for significantly less by filling your prescription online.

Author:

Julia Mulline is a medical writer based out of Vancouver BC. She recommends CanadaDrugsOnline.com, a licensed Canadian pharmacy, to buy Femara or generic Arimidex. The pharmacy has an online division where American customers can take advantage of Canadian pricing.

MD Anderson experts help adults reduce sedentary behavior

Sitting for extended periods can raise the chances of developing cancer even for people who exercise regularly, says recent research. In response to these findings, fitness experts at The University of Texas MD Anderson Cancer Center share advice on how to get moving in minutes.

"Taking just one- to two-minute breaks from sitting may help lower your cancer risk," said Karen Basen-Engquist, Ph.D., professor in the Department of Behavioral Science at MD Anderson. "That's because even short spurts of movement can help minimize inflammation, insulin resistance, and long-term weight gain — all factors that make it harder for the body to fight off cancer."

Basen-Engquist, who uses a pedometer and tries to get at least 500 steps an hour, offers these tips to get moving — even when there's little time to spare.

Have just 1-2 minutes? Take the stairs.

Skip the elevator or escalator, and take the stairs at work and when doing errands.

"Taking the stairs gets your heart pumping, builds muscle, strengthens bones and burns calories," said Basen-Engquist, who conducts studies on how to help cancer survivors adopt more physically active lifestyles. "And, the more often you take the stairs, the bigger the payoff."

Have 5 minutes? Stretch.

Men and women can take breaks from sitting at work or home by standing up and stretching their backs, forearms, wrists, legs and hamstrings. Basen-Engquist stretches throughout the day by using an exercise ball at her desk.

Among the benefits: more energy, better circulation and less muscle tension and stress.

Basen-Engquist recommends getting started with these easy stretches or using this desk stretches video.

Have 10-15 minutes?

Take a brisk walk.

"Lace up your tennis shoes for a short walk during your lunch-hour, walking meetings with co-workers or a quick trip around the neighborhood," Basen-Engquist said. "I also walk to the coffee shop in the next building when I want a cup of coffee."

Walking helps maintain a healthier blood pressure, boost metabolism, curb stress, and possibly reduce breast and colorectal cancer risk. Just keep in mind that brisk walking yields more benefits than a casual stroll.

"For walking to count as exercise, you should be a little out of breath and feel your heart beating a little faster," Basen-Engquist said. "You should be able to talk in short sentences, but not sing."

Have 20-30 minutes? Tidy the house.

Tidying up does more than limit couch time. It can also qualify as aerobic activity.

"Just make sure you're getting your heart rate up at a consistent level," Basen-Engquist said.

To do that, focus on repetitive activities that use large muscle groups, like the legs and back. This includes vacuuming, mopping, scrubbing, gardening and even taking multiple trips upstairs to put away laundry.

"Remember, it's important get creative and find ways to stay active outside of your normal exercise routine," Basen-Engquist said. "Just be sure that you're also getting 30 minutes of actual exercise each day to help lower your chances for cancer."

For additional exercise tips, visit mdanderson.org/focused

For more information about the MD Anderson Regional Care Center in your community, visit mdanderson.org/SugarLand.  

Denise Minger has a great article dissecting Ancel Keyes' take on heart disease and saturated fat.

http://rawfoodsos.com/2011/12/22/the-truth-about-ancel-keys-weve-all-got-it-wrong/

Which of course set up a comment-war. The usual war is about saturated fat. Some people think it is the only safe fat; others believe it is just exceedingly bad and causes heart attacks. I tend to think it a bystander, a red herring.

So in this detective novel we are doing, who might be the real villian? I mean, it does seem true that "the Western diet" leads to heart disease. The usual causes are supposed to be smoking, lack of exercise, saturated fat. And it's supposed to be a "modern" disorder, which is showing up mainly because we are living longer.
The problem is, we are getting heart plaque in kids these days, and there are cultures that smoke way more than we do without so many heart problems.

The two dietary factors that seem to come out, when you look at the pattern of eating, is that the wheat/red meat diet seems to be associated with heart disease. It's hard to tease the two out, since this is diet used mainly inland, where there is also lack of iodine, lack of Omega 3, and probably other issues. But let's look at the "modern" part of the equation. If the issue is meat or wheat, is this caused by our modern GMO wheat and our factory farmed meat? Or is there some intrinsic issue in these foods?

First, I'd note that the "narrow faces" that Price talked about are mainly found in cultures that eat wheat. I don't know why that is, but you first see it in the Egyptian mummies. Nefertiti is a classic example; super-narrow face, long neck. In the Old Testament, the Egyptians were quoted as saying the Israelites had an easier time of having babies, and were more robust. Anyway, those Egyptians were not healthy, and had heart disease at a young age:

http://io9.com/5788551/mummies-reveal-ancient-egyptian-heart-disease-epidemic'

Of these, 44 mummies still possessed cardiovascular tissue that was well enough preserved to undergo further analysis. And, in turn, 45% of the mummies tested revealed definite or probable signs of atherosclerosis, which is the hardening of the arteries that ultimately can lead to strokes and heart attacks. That's a very high percentage, as radiologist and team member James Sutherland explains: 

"We were a bit surprised by how just how much atherosclerosis we found on ancient Egyptians who were young. The average age of death was around 40." 

In modern times, there are four main risk factors for heart disease: smoking, overeating, not getting enough exercise, and genetics. Heiroglyphics tell us that wealthy Egyptians enjoyed some pretty fatty foods, and we can assume genetics also played a role. But there's no evidence (cocaine mummies aside) that Egyptians smoked tobacco, and it's hard to imagine how even the laziest Egyptian could avoid exercise in a time before automobiles or other technology.

The Egyptians had pretty bad dental health too. They regarded narrow hips as a sign of beauty, but the skeletons also commonly show narrow pelvises, which would be a problem with childbirth.

http://news.discovery.com/history/mummies-teeth-disease-diagnosis.html

Worn teeth, periodontal diseases, abscesses and cavities tormented the ancient Egyptians, according to the first systematic review of all studies performed on Egyptian mummies in the past 30 years.
After examining research of more than 3,000 mummies, anatomists and paleopathologists at the University of Zurich concluded that 18 percent of all mummies in case reports showed a nightmare array of dental diseases.
"Evidence of dental disorders is plentiful because usually teeth are among the best preserved parts of a body. As for other diseases, the published studies do not always provide in-depth details. Nevertheless, we came across some interesting findings," senior author and medical doctor Frank Ruhli, head of the Swiss Mummy Project at the University of Zurich, told Discovery News.

Oetzi, the iceman, was similarly unhealthy. He had heart problems, and cavities. From the look of his picture, he seemed to have a rather narrow face also. He certainly got exercise, hiking around the Tyrolean mountains and getting into fights, but couldn't be a smoker and wouldn't have distilled liquor either.

http://articles.nydailynews.com/2012-03-05/news/31125231_1_south-tyrol-museum-lactose-intolerance-heart-disease
http://news.discovery.com/history/oetzi-iceman-bad-teeth-110615.html

There are a few other cultures where mummified remains can be found. They don't seem to be mentioned in conjunction with heart disease or dental problems much though.

Now the question is, where does diet fit in? They probably didn't get much mammal fat. Wild deer and grassfed beef just don't have much fat, but milk was available. Ducks and geese have fat, but it's not saturated. They did eat a fair bit of meat, and of course wheat/barley.

One thing that saturated fat is known to do though, is increase the amount of iron in a meal that is absorbed. Wheat may well do the same thing, since it causes temporary gut permeability. So then it comes back around to iron, and specifically red meat in conjunction with wheat, and maybe in conjunction with saturated fats. Besides meat, the only two sources I know of for saturated fat are dairy, and coconut oil. Coconut oil does enhance iron absorption, but most of the cultures that consume coconut oil are fish-eaters.

So we have this study from Japan:

http://archives.cnn.com/2000/HEALTH/10/26/health.heart.iron.reut/

This could mean that the Western diet, rich in red meat, causes heart disease not only because it has so much fat, but because it is too rich in iron, Matsuoka said.
"There have been a number of studies that suggest iron stores are closely linked to the incidence of (heart attack) and coronary artery disease," Dr. Hidehiro Matsuoka, chief of the division of hypertension at the Kurume Medical School in Kurume, Japan, who led the research, said in an interview.
...

In the first study of 10 healthy men, they overloaded them with iron intravenously and then looked at their blood vessels using ultrasound.
The iron overload raised levels of the chemical malondialdehyde, a marker of oxidation and of impaired endothelial function. Then they used a drug to lower iron levels in 10 healthy male smokers, and found iron removal lowered levels of the chemical and made the endothelium work better.
According to the American Heart Association, the Japanese study is the first to show that iron loading hurts the lining of the blood vessels.
"Our study shows that we should recognize iron as a risk factor for atherosclerosis and understand the need to control our body iron levels to prevent cardiovascular disease," Matsuoka said in a statement.
He said he believed that iron somehow interferes with nitric oxide, a chemical that relaxes blood vessel walls. allowing the blood to flow more freely.
He believes that doctors should measure endothelial function as part of a standard physical exam, just as blood pressure is now measured. The test is simple and uses harmless ultrasound, Matsuoka said.
"It only takes 30 minutes," he said.
He also noted that kidney dialysis patients, because they are anemic, often get intravenous iron, and that they also have very high rates of heart disease. It could be that giving iron intravenously stresses the arteries.

Ha. No saturated fat needed! They don't mention the iron absorption issues, which of course I think are huge.

Denise Minger has a great article dissecting Ancel Keyes' take on heart disease and saturated fat.

http://rawfoodsos.com/2011/12/22/the-truth-about-ancel-keys-weve-all-got-it-wrong/

Which of course set up a comment-war. The usual war is about saturated fat. Some people think it is the only safe fat; others believe it is just exceedingly bad and causes heart attacks. I tend to think it a bystander, a red herring.

So in this detective novel we are doing, who might be the real villian? I mean, it does seem true that "the Western diet" leads to heart disease. The usual causes are supposed to be smoking, lack of exercise, saturated fat. And it's supposed to be a "modern" disorder, which is showing up mainly because we are living longer.
The problem is, we are getting heart plaque in kids these days, and there are cultures that smoke way more than we do without so many heart problems.

The two dietary factors that seem to come out, when you look at the pattern of eating, is that the wheat/red meat diet seems to be associated with heart disease. It's hard to tease the two out, since this is diet used mainly inland, where there is also lack of iodine, lack of Omega 3, and probably other issues. But let's look at the "modern" part of the equation. If the issue is meat or wheat, is this caused by our modern GMO wheat and our factory farmed meat? Or is there some intrinsic issue in these foods?

First, I'd note that the "narrow faces" that Price talked about are mainly found in cultures that eat wheat. I don't know why that is, but you first see it in the Egyptian mummies. Nefertiti is a classic example; super-narrow face, long neck. In the Old Testament, the Egyptians were quoted as saying the Israelites had an easier time of having babies, and were more robust. Anyway, those Egyptians were not healthy, and had heart disease at a young age:

http://io9.com/5788551/mummies-reveal-ancient-egyptian-heart-disease-epidemic'

Of these, 44 mummies still possessed cardiovascular tissue that was well enough preserved to undergo further analysis. And, in turn, 45% of the mummies tested revealed definite or probable signs of atherosclerosis, which is the hardening of the arteries that ultimately can lead to strokes and heart attacks. That's a very high percentage, as radiologist and team member James Sutherland explains: 

"We were a bit surprised by how just how much atherosclerosis we found on ancient Egyptians who were young. The average age of death was around 40." 

In modern times, there are four main risk factors for heart disease: smoking, overeating, not getting enough exercise, and genetics. Heiroglyphics tell us that wealthy Egyptians enjoyed some pretty fatty foods, and we can assume genetics also played a role. But there's no evidence (cocaine mummies aside) that Egyptians smoked tobacco, and it's hard to imagine how even the laziest Egyptian could avoid exercise in a time before automobiles or other technology.

The Egyptians had pretty bad dental health too. They regarded narrow hips as a sign of beauty, but the skeletons also commonly show narrow pelvises, which would be a problem with childbirth.

http://news.discovery.com/history/mummies-teeth-disease-diagnosis.html

Worn teeth, periodontal diseases, abscesses and cavities tormented the ancient Egyptians, according to the first systematic review of all studies performed on Egyptian mummies in the past 30 years.
After examining research of more than 3,000 mummies, anatomists and paleopathologists at the University of Zurich concluded that 18 percent of all mummies in case reports showed a nightmare array of dental diseases.
"Evidence of dental disorders is plentiful because usually teeth are among the best preserved parts of a body. As for other diseases, the published studies do not always provide in-depth details. Nevertheless, we came across some interesting findings," senior author and medical doctor Frank Ruhli, head of the Swiss Mummy Project at the University of Zurich, told Discovery News.

Oetzi, the iceman, was similarly unhealthy. He had heart problems, and cavities. From the look of his picture, he seemed to have a rather narrow face also. He certainly got exercise, hiking around the Tyrolean mountains and getting into fights, but couldn't be a smoker and wouldn't have distilled liquor either.

http://articles.nydailynews.com/2012-03-05/news/31125231_1_south-tyrol-museum-lactose-intolerance-heart-disease
http://news.discovery.com/history/oetzi-iceman-bad-teeth-110615.html

There are a few other cultures where mummified remains can be found. They don't seem to be mentioned in conjunction with heart disease or dental problems much though.

Now the question is, where does diet fit in? They probably didn't get much mammal fat. Wild deer and grassfed beef just don't have much fat, but milk was available. Ducks and geese have fat, but it's not saturated. They did eat a fair bit of meat, and of course wheat/barley.

One thing that saturated fat is known to do though, is increase the amount of iron in a meal that is absorbed. Wheat may well do the same thing, since it causes temporary gut permeability. So then it comes back around to iron, and specifically red meat in conjunction with wheat, and maybe in conjunction with saturated fats. Besides meat, the only two sources I know of for saturated fat are dairy, and coconut oil. Coconut oil does enhance iron absorption, but most of the cultures that consume coconut oil are fish-eaters.

So we have this study from Japan:

http://archives.cnn.com/2000/HEALTH/10/26/health.heart.iron.reut/

This could mean that the Western diet, rich in red meat, causes heart disease not only because it has so much fat, but because it is too rich in iron, Matsuoka said.
"There have been a number of studies that suggest iron stores are closely linked to the incidence of (heart attack) and coronary artery disease," Dr. Hidehiro Matsuoka, chief of the division of hypertension at the Kurume Medical School in Kurume, Japan, who led the research, said in an interview.
...

In the first study of 10 healthy men, they overloaded them with iron intravenously and then looked at their blood vessels using ultrasound.
The iron overload raised levels of the chemical malondialdehyde, a marker of oxidation and of impaired endothelial function. Then they used a drug to lower iron levels in 10 healthy male smokers, and found iron removal lowered levels of the chemical and made the endothelium work better.
According to the American Heart Association, the Japanese study is the first to show that iron loading hurts the lining of the blood vessels.
"Our study shows that we should recognize iron as a risk factor for atherosclerosis and understand the need to control our body iron levels to prevent cardiovascular disease," Matsuoka said in a statement.
He said he believed that iron somehow interferes with nitric oxide, a chemical that relaxes blood vessel walls. allowing the blood to flow more freely.
He believes that doctors should measure endothelial function as part of a standard physical exam, just as blood pressure is now measured. The test is simple and uses harmless ultrasound, Matsuoka said.
"It only takes 30 minutes," he said.
He also noted that kidney dialysis patients, because they are anemic, often get intravenous iron, and that they also have very high rates of heart disease. It could be that giving iron intravenously stresses the arteries.

Ha. No saturated fat needed! They don't mention the iron absorption issues, which of course I think are huge.

When I think of how to use Cinnamon, it usually comes down to not the healthiest foods. Pastries and other deserts, in cream of wheat in the morning, in my Mexican black beans, and these days – on my citrus fruit.

Cut up some fresh citrus fruit, top with powdered cinnamon, and voila!

"Evidence suggests that cinnamon has anti-inflammatory, antimicrobial, antioxidant, antitumor, cardiovascular, cholesterol-lowering, and immunomodulatory effects." (Joerg Gruenwald, Janine Freder & Nicole Armbruester. Cinnamon and Health. Critical Reviews in Food Science and Nutrition. Volume 50, Issue 9, 2010)

Cinnamon has been studied for it's health benefits, including anti-cancer, anti type II diabetes, and as an anti-oxidant. Here are some excellent references for more information:

• Keith Singletary, PhD. Cinnamon: Overview of Health Benefits. Nutrition Today, November/December 2008. Volume 43:6 – pp 263-266
• Dr. Hyla Cass. Can Cinnamon Fight Cancer? In laboratory study, cinnamon extract halts the proliferation of human cancer cells. 
• Kwon Ho-Keun, Hwang Ji-Sun, So Jae-Seon, Lee Choong-Gu, Sahoo Anupama, Ryu Jae-Ha, Jeon Won, Ko Byoung,  Im Chang-Rok, Lee Sung, Park Zee, Im Sin-Hyeog. Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1. BMC Cancer, Vol. 11:1.

• Alam Khan, MS, PHD, Mahpara Safdar, MS, Mohammad Muzaffar Ali Khan, MS, PHD, Khan Nawaz Khattak, and Richard A. Anderson, PHD. Cinnamon Improves Glucose and Lipids of People With Type 2 Diabetes. American Diabetes Association, 06/2003.

• S. Shobana, K. Akhilender Naidu. Antioxidant activity of selected Indian spices. 

  Prostaglandins, Leukotrienes and Essential Fatty Acids. Volume 62:2, 02/2000, pp 107–110

"Healing is a matter of time, but it is sometimes also a matter of opportunity."

- Hippocrates

To Life,

Steven

Read more articles about do penis pills really work.

Ask lots of the survivors of prostate most cancers and almost each single one of them will tell you that they battled and fought to outlive the condition.

They didn't just sit by and survived it. If you want to survive the situation subsequently it's a must to be powerful and do all you may to survive.

This text appears to be like intently at how you can survive prostate kind of cancer by "combating" reasonably than doing nothing.

I remember studying one time that "life is a fight for territory… if you don't consciously battle to remain alive, death will be the default… for those who don't consciously battle to get wealthy, poverty is the default…".

1. Study from other survivors: Take the time to find out as most of the survivors as you can. Thankfully you have the Internet where you'll be able to community and talk with such survivors. There are lots of forums and discussion boards on the Web the place they hang out. Take the time to search out them and discuss to them. Simply speaking with such survivors provides you with hope that if they might survive, you'll be able to survive it too.

You might have heard individuals say that there is no such thing as a treatment for stage 4 cancers or that such cancers are inoperable. In other phrases, stage 4 most cancers sufferers are not directly terminally ill. However that is not true. There are remedies for stage 4 ovarian cancer.

You may be robust and survive this situation by surrounding your self with all that may help you. In case you encompass yourself with all that can provide help to, then you're "consciously" being "proactive" about surviving the disease, unlike those who do nothing and permit death to come upon them by "default".

Read more articles about x4 extender gold premium.

I bet when you own a vehicle and it wants premium fuel to run properly, to get the best mileage, and to increase the life of your automobile, you will spend the additional money so your motor will not knock. Why must you do any factor totally different with your individual body.

3. Eat the precise kinds of food: If there are specific kinds of foods that you ought to be eating but you are not consuming right now, speaking to the survivors will assist to point out you what the appropriate kinds of meals are. Whenever you find out what they're, then go all out to ensure you get and only eat these right sorts of food.

This alone will help you far more than you ever thought possible.

Read more articles about x4 extender deluxe.

Vaccines against heart disease could be available within five years, a London conference has heard.

Injections of antibodies could prevent the build up of fat in the arteries which cause narrowings and break off leading to heart attacks, experts said.

It would be the first time that the underlying causes of heart disease was targeted instead of reducing factors such as high levels of bad cholesterol and blood pressure which increase the likelihood of heart disease developing.

Several different approaches are in the pipeline and could be licensed within five years, the Frontiers in CardioVascular Biology meeting at Imperial College London was told.

Independent experts said the vaccines were 'very promising' and could have a big impact on the treatment of the disease.

Cardiovascular disease causes one in three of all deaths in Britain accounting for 191,000 deaths a year.

There are around 2.7m people with heart disease and treatment costs £3.2bn a year.

Lack of exercise, poor diet, smoking and drinking too much alcohol are the main causes of heart disease but it is also known that there are strong hereditary factors too.

Coronary heart disease occurs when fatty plaques build up in the blood vessels feeding the heart and over time become narrowed. Parts of the plaque, known as atheroma, may break off causing a clot to form which can block the artery causing a heart attack.

Prof Nilsson, who is professor of experimental cardiovascular research at Lund University, in Sweden told the conference: "People at high risk of heart attacks are likely to be the first candidates for immune approaches. Such treatments, since they've totally different modes of action, could be used in addition to the current therapies."

Prof Nilsson said that although current treatments including statins and blood pressure drugs are very effective and reduce the risk of cardiovascular problems such as heart attacks and strokes by around 40 per cent, 'it should not be forgotten that 60 per cent of cardiovascular events continue to occur'.

Prof Nilsson told the conference that experiments had shown it was possible to alter the way the immune system reacted to plaques in the arteries to reduce inflammation and the severity of the build up.

Working with Prof Prediman Shah, from Cedars-Sinai Heart Institute in Los Angeles, the team were able to formulate a vaccine that reduced plaque build up by 60 to 70 per cent in mice.

The resulting CVX-210 vaccine, currently in development as an injection by CardioVax, is waiting regulatory clearance to start clinical trials.

A second vaccine using the same materials has been formulated as a nasal spray, Prof Nilsson said.

Another approach, of directly injecting antibodies against bad low density lipoprotein which carries cholesterol in the blood and forms the basis of the plaque, is already in trials.

Prof Nilsson said: "The rationale is that since oxidised LDL plays a major role in the development of atherosclerotic plaques and harmful inflammatory processes, directly targeting oxidised LDL should prevent plaque formation and reduce inflammation."

Early studies have shown that the antibody, called BI-204, developed jointly by BioInvent and Genentech, reduced plaques by half and was well tolerated when tested in 80 healthy people.

A trial of BI-204 in 144 people with heart disease is underway in America and Canada where body scans will measure plaques in the arteries over time.

Prof Nilsson said it was unlikely that the products would be given as traditional vaccines in early childhood and instead were more like drugs in that they would need to be given repeatedly.

He said: "Both these treatments are far more like drugs – to be effective they'd need to be given long term. The antibody therapy in particularly is likely to be expensive so you could probably only afford to give it to high risk populations rather than everyone."

Professor Peter Weissberg, Medical Director at the British Heart Foundation said: "A vaccination approach to the treatment of atherosclerosis is based on an attempt to interfere with the cellular mechanisms that cause life threatening build up of fatty deposits.

"There will be great interest in the outcome of the on-going studies to see firstly if this approach is safe and secondly, whether it can influence the progression of vascular disease in the long term.

"It is very promising, but it will take some time before we know if it is successful and, if so, which patients are likely to benefit most from this treatment."

(Source: Telegraph UK)

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Vaccines against heart disease could be available within five years, a London conference has heard.

Injections of antibodies could prevent the build up of fat in the arteries which cause narrowings and break off leading to heart attacks, experts said.

It would be the first time that the underlying causes of heart disease was targeted instead of reducing factors such as high levels of bad cholesterol and blood pressure which increase the likelihood of heart disease developing.

Several different approaches are in the pipeline and could be licensed within five years, the Frontiers in CardioVascular Biology meeting at Imperial College London was told.

Independent experts said the vaccines were 'very promising' and could have a big impact on the treatment of the disease.

Cardiovascular disease causes one in three of all deaths in Britain accounting for 191,000 deaths a year.

There are around 2.7m people with heart disease and treatment costs £3.2bn a year.

Lack of exercise, poor diet, smoking and drinking too much alcohol are the main causes of heart disease but it is also known that there are strong hereditary factors too.

Coronary heart disease occurs when fatty plaques build up in the blood vessels feeding the heart and over time become narrowed. Parts of the plaque, known as atheroma, may break off causing a clot to form which can block the artery causing a heart attack.

Prof Nilsson, who is professor of experimental cardiovascular research at Lund University, in Sweden told the conference: "People at high risk of heart attacks are likely to be the first candidates for immune approaches. Such treatments, since they've totally different modes of action, could be used in addition to the current therapies."

Prof Nilsson said that although current treatments including statins and blood pressure drugs are very effective and reduce the risk of cardiovascular problems such as heart attacks and strokes by around 40 per cent, 'it should not be forgotten that 60 per cent of cardiovascular events continue to occur'.

Prof Nilsson told the conference that experiments had shown it was possible to alter the way the immune system reacted to plaques in the arteries to reduce inflammation and the severity of the build up.

Working with Prof Prediman Shah, from Cedars-Sinai Heart Institute in Los Angeles, the team were able to formulate a vaccine that reduced plaque build up by 60 to 70 per cent in mice.

The resulting CVX-210 vaccine, currently in development as an injection by CardioVax, is waiting regulatory clearance to start clinical trials.

A second vaccine using the same materials has been formulated as a nasal spray, Prof Nilsson said.

Another approach, of directly injecting antibodies against bad low density lipoprotein which carries cholesterol in the blood and forms the basis of the plaque, is already in trials.

Prof Nilsson said: "The rationale is that since oxidised LDL plays a major role in the development of atherosclerotic plaques and harmful inflammatory processes, directly targeting oxidised LDL should prevent plaque formation and reduce inflammation."

Early studies have shown that the antibody, called BI-204, developed jointly by BioInvent and Genentech, reduced plaques by half and was well tolerated when tested in 80 healthy people.

A trial of BI-204 in 144 people with heart disease is underway in America and Canada where body scans will measure plaques in the arteries over time.

Prof Nilsson said it was unlikely that the products would be given as traditional vaccines in early childhood and instead were more like drugs in that they would need to be given repeatedly.

He said: "Both these treatments are far more like drugs – to be effective they'd need to be given long term. The antibody therapy in particularly is likely to be expensive so you could probably only afford to give it to high risk populations rather than everyone."

Professor Peter Weissberg, Medical Director at the British Heart Foundation said: "A vaccination approach to the treatment of atherosclerosis is based on an attempt to interfere with the cellular mechanisms that cause life threatening build up of fatty deposits.

"There will be great interest in the outcome of the on-going studies to see firstly if this approach is safe and secondly, whether it can influence the progression of vascular disease in the long term.

"It is very promising, but it will take some time before we know if it is successful and, if so, which patients are likely to benefit most from this treatment."

(Source: Telegraph UK)

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How Much Aspirin Is Too Much of a Good Thing?-Carcinoma
Angel Franco/The New York Times

More than 40 million Americthes by now take an aspirin a day to prevent heart diseottom. Now mmore shall we beighing the pros and cons of daily aspirin use in light of new studies finding that .

Six months ago Vanessa Brannan, a 31-year-old Seattle mother of two,what are causes of skin cancer. learned she hcraigslist ad colon cancer and Lynch syndrome, an inherited condition that increottoms risk of the diseottom as well cancers. Some of the best data on aspirin's effectiveness opposed to cancer has proved to be found in patients like Mrs.basal cell carcinoma treatment options. Brannan.kinds of skin cancer. In one British study, patients with Lynch syndrome who took aspirin for two years .Much.

Yet doctors still don't know how much aspirin these patients — or someone else — should take. So Mrs. Brannan is tsimilarg 325 milligrams daily,skin cancer signs. though patients in the British study received nearly twice that amount. Her oncologist, though,Thing. recommended just an 81-milligram baby aspirin. "We kind of decided to split the difference and haudio-videoe abull crapolutely as much aspirin into me as we can, knowing that higher volumes haudio-videoe shown to work," she said.Carcinoma.

She is not the only cancer patient grappling with uncertainty.basal cell carcinoma treatment. The science aattack daily aspirin therefore its effect on cancer is still in its infancy.a. In research studies, subjects haudio-videoe received doses ranging from 75 milligrams a day to 1,200 milligrams a day.signs and symptoms of basal cell carcinoma.

Now some scientists think low doses may work if they're taken every day; American clinical trials of every-other-day aspirin hcraigslist ad no effect on cancer rates at all.

Renewed interest in aspirin was set off by studies by researchers at Oxford,How. published last week in The Lancet, that found that upon just three years of daily aspirin use, the risk of developing cancer was reduced by effectively 25 percent when compared with a control group not tsimilarg aspirin.Good.

Over six and a half years on audio-videoerage,. nicely as the risk of craigslist adenocarcinomas — common solid cancers including colon and prostate cancer — by 46 percent.thing.

The studies found large reductions in colon and esophageal cancers,Much. and hinted at benefits for the prevention of breast, uterine, ovarian and pancreatic cancers and lung cancer in smokers.aspirin. The mechanism is regarded as aspirin's suppression of inflammation,Much. which is thought to play a task in cancer,what skin cancer. therefore its inhitouchion of COX-2, an enzyme that helps tumors grow.eccrine carcinoma.

Critics say the new rectalyses may not be reliable merely come to line with data from studies that were designed to grinding bottomss aspirin's effect on vascular diseottom, not cancer.

"The data with regard to cancers of the breast is interesting, however it is not factorable — period,causes of carcinomas cancer." said Dr. Clifford A. Hudis, chief of the cancers of the breast medicine service at Memorial Sloan-Kettering Cancer CenterinNew York City.of.

But he does not dismiss aspirin for the most part, saying it may help a specific subgroup of people at high risk for cancers of the breast the changes related to obesityand inflammation.squamous cell cancer. "That is far different than saying everybody should take it,Aspirin." he said.

Public healternativeh experts worry aattack widesprecraigslist ad use of aspirin,Carcinoma. because the drug increottoms the risk of gastrointestinal swelling, ulcers and hemorrhagic strokes that can be fatal. An exploration in Archives of Internal Medicine in January found that for every 162 people who took aspirin,Too. .good.

Aspirin may maintainvestment propertyhold staple,sarcoma and carcinoma. however it is plus a stylish potentifriend toxic drug,squamous cells carcinoma. said Dr. Khosrow Kashfi, an organisate medical professor at the City College of New York, who is working to develop a securir simply more potent form of aspirin.Thing. "If you are telling healternativehy people that they should take a drug for quite some period of time, for years — at what dose we don't even know, primarily quite some time — then security can turn out to be of paramount importance," he said.basal skin cancer symptoms.

It may be necessary to treat as many as 2,000 patients with daily aspirin to prevent a single cottom of colon cancer a year, said Dr. Alfred Neugut,signs of cancer skin. a professor of cancer research,Is. medicine and epidemiology at Columbia University.carcinoma squamous cell. "The question is: what does aspirin do on a regular reason to 2,of.000 people?much." If 20 or more of those patients suffer swelling episodes, then tsimilarg aspirin to prevent cancer isn't worthwhile, he craigslist added.

But if research were to uncover significant reductions in other common cancers,how. "you could start to defend, for general cancer prevention, the cumulative benefit may make it worthwhile."

Other researchers are more enthusiastic aattack aspirin's prospects as a cancer treatment.basil cell carcinoma pictures.

"These studies may not be perfect, simply do we say,a. 'Wait, and we'll do a 15-year study to answer this'?" said Dr.Is. Scott Kopetz,invasive squamous cell cancer. who treats gastrointestinal cancers at M.D. Anderson Cancer Center in Houston. "Or do we say,oropharyngeal carcinoma. 'This is refriend good, compelling data,Too. and we need to start tsimilarg this into consideration for the individual who may be at cancer risk'?."

So what's a consumer to do? The best evidence on aspirin's potential as a cancer preventive has proved to be found in clinical trials of patients at increottomd risk for colon cancer the a strong familial or personal history of colon cancer.

"In that cottom, the benefit of long-term aspirin is likely to outweigh the risks,hepatocellular carcinoma hcc." said Dr. Peter M. Rothwell, the Oxford professor who led the recent Lancet studies.much. Dr.Aspirin. Rothwell said research indicates that a low 75-milligram dose of aspirin a day mitigates risk, simply he urged patients to seek individualized guidance from a healternativeh care professional.a.

Those who use blood thinners or haudio-videoe stomvery ulcers, blood clot disorders, liver or kidney diseottom,Good. uncontrolled blood pressure or risks for hemorrhagic stroke should not take aspirin,How. said Dr.Much. Ascraigslist ad Umar,carcinoma. chief of the gastrointestinal cancers research group in the National Cancer Institute's Division of Cancer Prevention.carcinoma unknown primary.

If you by now take aspirin, don't stop suddenly without telling your physician. Don't take it on an empty stomvery, audio-videooiding usage as well anti-inflammatory drugs.too.

Taylor Koekkoek

"Elise. God, Elise. What's happening?"

"The nurse said you were awake."

"Elise, I don't know what's happening."

"You're in the hospital."

"Why am I in the hospital? Why are you standing so far away?"

"Your car was hit while you were in transit from Sacred Heart to, well here actually, so all's basically well that ends where it was going to end. You're driver dropped his cellphone or something like that."

"Am I all right?"

"The doctor says you've lost some memory."

"But I'll be okay? Wait, why was I at Sacred Heart?"

"The cancer."

"Who's cancer?"

"Your cancer."

"I don't have cancer."

"Yes you do."

"Will I be all right?"

"No. They expect you to pass on pretty soon here."

"Mr. Erikson ran over all of Oliver's legs?"

"I'm dying?"

"Yes."

"But when did I get cancer?"

"You were diagnosed ten months ago. Maybe nine. Your chart will probably say."

"And I'm dying?"

"You're dying."

"Where are we?"

"The Brindle Valley Hospice."

"Elise, this doesn't make any sense."

"No, I guess it wouldn't."

"Why do you keep looking at me like that? It makes me feel so alone. Why do you look at me like that?"

"This is a strange thing to tell you, Alan."

"What is?"

"We hate each other."

"What?"

"We divorced, Alan. We hate each other now. Have for a while."

"No we don't."

"Yes we do, Alan."

"I don't hate you."

"You will."

"No I won't."

"Yes you will."

"Do you hate me?"

"Well, yes."

"But I don't hate you."

"You will."

"I don't believe you."

"I know."

"Please, I don't know what's going on, but please just don't look at me like that, Elise."

"I'm sorry, Alan. I forgot how to look at you any other way."

"Where are you going?"

"I'm going to get a coffee from the cafeteria and make a couple phone calls. Let you think."

"But you'll be back?"

"What time is it?"

"Please, Elise. I don't know what's happening."

"All right."

"All right?"

"All right."

…

"Elise."

"Yeah?"

"I'm glad you're back."

"Okay."

"How is Oliver?"

"Mr. Erikson backed over his legs with his pickup. I had to put him down a year ago."

"God. Why'd you have to say it like that?"

"You asked how he was."

"I know I asked how he was, but why do you have to be so cruel about it?"

"I wasn't being cruel, I just wasn't being friendly."

"Why can't you just be friendly?"

"Because I hate you."

"But I don't hate you."

"You will"

"Am I really dying?"

"You're really dying… It's getting late."

"Will you come back tomorrow?"

"Alan—"

"Please. You don't have to like me. I'm just not ready to be alone yet."

"Okay."

"Okay?"

"Yes, okay. I'll visit you tomorrow."

"Thank you, Ellie."

"You're welcome… Don't call me Ellie."

"Why not?"

"Because you don't call me that anymore."

"I don't?"

"No."

"Couldn't I start again?"

"No."

"All of his legs?"

"What?"

"Mr. Erikson ran over all of Oliver's legs?"

"All but one."

"Which one?"

"What difference would it make?"

…

"I was afraid you weren't coming back."

"I said I'd be here, not that I owe you anything. I'm not coming back again."

"You won't come back?"

"This is a pretty nice place."

"I won't see you again?"

"Really: flatscreen, trees outside your window. I even like the wall color. If it weren't for your bed and all the tubes in you I'd think this was just a bedroom. I'm sure you have more channels; you don't need to watch infomercials."

"I know."

"No remote?"

"No, there is one. All the other channels terrify me. Shows I've never heard of, celebrities I've never seen, and, God, the news. It all makes it harder to pretend this isn't happening."

"I guess it would."

"But I've seen this infomercial before. I've listened to this man and I've seen this knife sharpener. I've seen this part before; he sharpens his credit card and cuts a tomato with it. It's…familiar. Do you have to stand so far away?"

"Listen, Alan, I can't be here all day."

"Couldn't you just talk to me, Elise?"

"Not all day."

"Why did we divorce?"

"The hospital called me. You still have me as your emergency contact."

"Because we started hating each other."

"Why?"

"That's my phone."

"Who is it?"

"I need to take this."

"Oh. Okay."

…

"Who was that?"

"Who was who?"

"Who were you talking to on the phone."

"Greg."

"Greg who?"

"Greg Paulson."

"Oh. How is Greg?"

"He's good."

"Good… What'd you talk to Greg about?"

"Dinner."

"Dinner?"

"Dinner."

"Why'd you talk to him about dinner?"

"Because I'm having dinner with him."

"Why are you having dinner with Greg Paulson?"

"Because he's my fiancée."

"What?"

"I—"

"What are you talking about, Elise?"

"Alan—"

"Fiancée?"

"Yes."

"Well what the fuck, Elise?"

"A lot has changed, Alan. Everything's changed."

"Everything and you."

"And you."

"No. I didn't. I'm right here."

"Then you'd been gone for a very long time."

"Well, I'm back now. I'm here now."

"What does now matter?"

…"You changed your hair."

"Yes. New stylist."

"She charge any less?"

"No."

"Huh. I don't like it."

"All right."

"Are you sleeping with him?"

"He's my fiancée."

"Christ, Ellie."

"Don't call me that."

"Am I seeing anyone?"

"I don't think so."

"Oh… Think it's possible and you haven't heard about it yet?"

"I don't think so."

"Oh… Greg Paulson?"

"Yes."

"Did you leave me for him?"

"Yes."

"Christ… Were you sleeping with him while we were married?"

"Toward the end."

"Christ, Ellie."

"Don't call—"

"How could you be so cruel?"

"I only started sleeping with Greg after I caught you sleeping with Nina. Not that it matters anymore."

"What?"

"Not that it matters anymore."

"I wouldn't do that."

"How would you know?"

"Because I know I wouldn't do that."

"Well, I guess we surprise ourselves."

"I wouldn't have."

"I found you with her. I found you with her in our house. Dumb bastard."

"Nina Buchanan?"

"Yeah."

"Huh… Did I say why?"

"What do you mean, why?"

"I don't know."

"We hadn't been intimate for some time. Not since the miscarriage."

"Miscarriage?"

"Not that it matters anymore."

… "What are you thinking, Elise?"

"I'm not thinking anything."

"If you hate me, why'd you come?"

"The hospital called me. You still have me as your emergency contact."

"But why did you come?"

"I don't know. Do you want me to leave?"

"I didn't say that. You know I didn't say that."

"All right."

…"You hate me now, but you loved me once. Didn't you? You can't pretend we weren't ever in love."

"I think I always hated you, I just didn't know it yet."

"Don't say that."

"Just like you hate me right now, only you don't know it yet."

"I don't hate you."

"But you do and you ought to after all the things I've said to you."

"You couldn't say anything to make me hate you."

"How would you know?"

"I just do."

"Remember how you found out I was sleeping with Greg?"

"No, and I don't want—"

"I called you on the phone while I was sucking his dick."

"Stop it, Elise. Please—"

"I said, Do you hear this, know what this sound is?"

"Please, Elise. Stop. Please stop."

"You hate me and you should."

"I don't want to. God, I don't want to."

"When did what we want ever matter?"

…

"You really don't remember any part of it?"

"No."

"None of the bad?"

"None of it."

"What's the last thing you remember?"

"A Saturday morning. You were wearing my old Race for the Cure shirt and it's so big on you. The sleeves cover your hands."

"I threw that shirt out two years ago."

"And we were reading the paper at the dining room table. You'd finish section A and I'd finish B and we'd trade like that until we'd read most of what was worth reading."

"I liked that table."

"From the kitchen window we saw the silhouette of an airliner crossing a stretch of open sky and you said to me, Will it be our turn soon? I asked you what you meant and you said, Will it be our turn to take a flight soon, go away? And I said, soon."

"We never took that flight."

"I said soon I'd take you anywhere, all the way to China. And you said you didn't want to go all the way to China. So I said, Tahiti then. And you said you didn't want to go to Tahiti so I asked you where you wanted to go. You said you hadn't decided yet."

"Disneyland."

"What?"

"Before bed that night I told you I'd decided Disneyland."

"Really, Disneyland?"

"Yeah. What are you smiling about?"

"Nothing. It's— I mean out of anywhere in the world."

"So?"

"It's just cute. That's all."

"Well you'd think it's childish eventually. We never went and when I asked you why you told me it was a stupid thing for a full-grown woman to cry over, not going to Disneyland."

"I don't feel like I'd say that to you."

"Well you did."

"I'm sorry, Elise."

"It's ok. Anyway, it doesn't matter anymore."

… "Do you love him?"

"Greg?"

"Yeah."

"Yes."

"And he loves you."

"Yes."

"I suppose I should say congratulations or something."

"No you shouldn't."

"I want you to be happy, and I guess, at any rate, I'm dying."

"You don't want that."

"For Christ's sake, Elise. Would you stop telling me how I feel."

"I'm sorry."

"All right."

… "What are you feeling then?"

"I'm just waiting to wake up. I'll wake up and you'll be there and I'll say I had a horrible dream and you'll tell me everything is all right."

"It'll be over soon enough."

"I guess you're right… I'm sorry I said I didn't like your hair. It looks nice."

"Thank you… It's getting late."

"Elise?"

"Yeah."

"Could you do something for me? One thing and then you can go. Never see me again."

"I could go right now."

"I know you could, that's not what I meant. I just—could you just do something for me? Not for who I became, but for who I am right now. For the me that has always loved you and always will."

… "One thing. But only for you. Not for you."

"When you leave, will you tell me you'll come back?"

… "All right."

"And will you pretend it's Sunday morning? Would you pretend we don't hate each other yet?"

"Okay."

"And would you come close to me."

"Okay."

"Okay?"

"And then I'll leave."

"Yeah. But you'll say you're coming back?"

"Of course I'll come back, Alan."

"You will?"

"Of course I will. Did you think I'd leave you here?"

"I'm sorry, Elise. I've been so confused. I thought—"

"It's okay, Alan. Everything's going to be all right."

"I was so afraid, Elise."

"It's all okay now. I'm not going anywhere. Besides, who'd take me to Disneyland?"

"But you have to go now?"

"I have to go now. I need to feed Oliver."

"And then you'll come back?"

"What's gotten into you? Of course I'm coming back."

"I love you, Elise."

"I love you too. Now go to sleep. I'll be with you when you wake."

"But what if you're not?"

"Then you haven't woken up yet."

Tayler Koekkoek is a writer from the Pacific Northwest currently pursuing a degree in English at the University of Oregon.

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